Sarcomatoid Mesothelioma: A Deadly Curse Of Asbestos

by Kirsten Hawkins

Sarcomatoid Mesothelioma is a quite uncommon type of cancer caused due to asbestos exposure. While it is difficult to diagnose Sarcomatoid Mesothelioma, it hardly responds to any type of therapy. This is the most serious of all asbestos-related diseases. The possibility of finding this type of cancer is on the lips and the larynx. However, in certain cases it may affect the oral cavity as well. Like all other forms of mesothelioma cancers, this cancer is a fatal disease and hardly responds to any method of treatment. Even though radiation therapy is recommended for the treatment of these cancerous tumors, but some of them may not be radiosensitive and may defy radiation for treatment.

A Quick Guide to Asbestos and Health Issues

Gerard Simington

Unless you have been completely out of touch, you have probably heard all the hubbub about the dangers of asbestos. So, what is the big deal?

A Quick Guide to Asbestos and Health Issues

Asbestos is a fibrous material that is highly resistant to burning. It has a long history. While it was first used on a large scale commercial basis at the turn of the twentieth century, it has actually been around much longer. In fact, the ancient Egyptians were known for using it burial clothes.

Common modern applications used to include building materials, products and automobile brake pads, which all required a fire resistant element. Asbestos is still used today, but on a fairly small scope. The reason has everything to do with health. Asbestos in and of itself is not harmful to people. What is harmful, however, is asbestos dust.

Asbestos dust is a vicious thing. Due to the chemical makeup of the material, the dust is like a cloud of fine glass particles. While they will not damage your skin, they do great damage to the lungs. Making matters worse, asbestos dust is so fine that it is easily raised from asbestos material like ceiling tiles and walls. Once in the air, it is all but invisible. Prolonged exposure, such as when working on or in a building with asbestos materials, can result in massive amounts of the toxic dust entering the lungs.

Once asbestos dust is in your lungs, you cannot expel it by coughing. That doesn’t mean the body does not try. Asbestosis is scarring of the lungs from acid created by the body in an effort to get the asbestos dust out. If this process is allowed to occur for 10 to 20 years, the lungs may stop functioning because of excess scarring. If that sounds bad, it only gets worse. Asbestos dust can lead to terminal cancer in the form of mesothelioma. [What is Mesothelioma?]

Asbestos is an excellent fire resistant material that saves us from burning while killing us in a much slower manner. Since 1989, it has been banned in the United States in all but a few commercial areas.

Gerard Simington is with FindAnAttorneyForMe.com - offering asbestos and mesothelioma legal information.

Diagnosis of Sarcomatoid Mesothelioma:

The differentiation of sarcomatoid mesothelioma from other cell tumors by light microscopy is quite difficult. The role of immunohistochemistry is also not well defined in its diagnosis. Since sarcomatoid mesothelioma is not always cytokeratin-negative, the distinction between it and sarcoma is not always possible. In this context, the doctors undertook a study to investigate the utility of diagnostic immunohistochemistry for distinguishing sarcomatoid mesothelioma from its histological mimics, high-grade sarcoma and pulmonary sarcomatoid carcinoma.

For its study, the researchers stained the mesotheliomas with sarcomatoid components. They assessed the intensity and distribution of staining with the help of a semi quantitative scale. Only tumors with unequivocal staining were considered positive for tabulation. Then they compared the immunophenotypic profiles of these tumors with 24 high-grade sarcomas. The sarcomatoid carcinomas were also stained for thyroid transcription factor-1 (TTF-1).

The study showed that Cytokeratin 5/6 stained most of the epithelioids but the sarcomatoids were rarely stained. On the other hand, Calretinin and thrombomodulin each stained 70% of sarcomatoid. All 10 sarcomatoids were negative for TTF-1. This led to the conclusion that a wide immunophenotypic overlap exists among different sarcomatoids. Cytokeratin and calretinin have the most value in differentiating different sarcomatoids. Clinicopathological data, especially information about the gross appearance of the tumor is quite important for sarcomatoid tumors. Thus, it should be noted and carefully correlated with microscopic and immunohistochemical findings.
About the Author

Kirsten Hawkins is a asbestos and mesothelioma specialist from Nashville, TN. Visit http://www.asbestosblog.org/ for information on asbestos reform, mesothelioma lawsuit news, and more.

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