Rheumatoid Arthritis
by Charlene J. Nuble
A shooting pain in the knee. A burning
sensation in the hand. Before you know it, you have rheumatoid
arthritis.
Rheumatoid arthritis is a chronic inflammation of the
joints. Rheumatoid arthritis is an autoimmune disease in which
the immune system attacks normal tissues as if they were
invading antibodies. Rheumatoid arthritis also causes
inflammation of the tissues around the joints and other organs
of the body. The hands and feet are the most affected areas of
rheumatoid arthritis although it can also affect any joint
lined by a membrane. Rheumatoid arthritis
is referred to as a systematic illness and sometimes called
rheumatoid disease.
Rheumatoid arthritis manifests itself over a period of a few
months. However, for some, the disease appears overnight.
Accelerated onset of rheumatoid arthritis does not mean the
individual is at greater risk of the progression of the
disease. Rheumatoid arthritis can lasts for years without
symptoms. But rheumatoid arthritis is an illness that
progresses and has the potential to cause joint destrution and
functional disability. Usually, patients suffer cycles from
severe to light symptoms. In terms of statistics, rheumatoid
arthritis is three times more common in women than in men. It
also besets people of all races equally. Rheumatoid arthritis
can begin at any age but most often start in the early
forties.
What causes rheumatoid arthritis? The truth is, its cause is
still unknown. Viruses, bacteria, and fungi have long been
suspected but none has been proven to be the cause. The cause
of rheumatoid arthritis has been the focus of different
research activities. There are some scientists who believe that
the tendency to develop rheumatoid arthritis may be genetically
inherited while others believe that certain factors in the
environment might elicit the immune system to attack the body's
own tissue components. This attack results to the inflammation
in various organs such as lungs or eyes.
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Drug Therapies for
Rheumatoid Arthritis
Rheumatoid arthritis is a
progressive disease that
affects over two million
Americans. Symptoms may include
joint stiffness, muscle ache,
and general discomfort. As a
progressive disease, it is
expected that most patients
will experience a worsening of
symptoms as time progress.
Fortunately, there are many
drug therapies available to
patients that can help
alleviate the patient's
symptoms considerably. The
primary goal of therapy
consists of helping alleviate
the symptoms associated with
rheumatoid arthritis so that
the patient can take part in
all their normal activities
with as little pain or
discomfort as possible.
Sometimes, the patient may have
to learn to modify their
activities in order to prevent
damage or discomfort. For the
most part, however, individuals
with rheumatoid arthritis can
lead healthy lives. Drug
therapies are prescribed
according to each individual's
specific circumstances and
symptoms. Many times, two or
more drug therapies are used in
conjunction with one another to
achieve the best possible
results.
Traditional drug therapies
consist of anti-inflammatory
drugs. These are often referred
to as NSAIDs. NSAIDs are
non-steroidal and are targeted
at reducing mild to moderate
symptoms associated with
inflammation caused by
rheumatoid arthritis. For more
advanced cases of rheumatoid
arthritis, doctors often
prescribe a specific class of
drugs, often referred to as
DMARDs. These are also known as
disease-modifying antirheumatic
drugs, sometimes also referred
to as glucocorticoids. DMARDs
should ideally be prescribed at
the early stages of treatment.
Research has shown that DMARDs
are most effective when
indicated at the beginning of
treatment. In fact, DMARD drugs
tend to be avoided for advanced
cases of rheumatoid arthritis
because they have been shown to
cause serious side effects. If
prescribed early enough, DMARDs
have been shown effective at
relieving signs of joint
damage.
The conventional approach to
treating rheumatoid arthritis
with drugs consists of
prescribing DMARD drugs to the
patients as early as possible
after a positive diagnosis.
Studies indicate that if a
patient is treated
approximately three to twelve
moths after the symptoms of
rheumatoid arthritis have been
first noticed the patient has a
considerably greater chance of
going into remission. DMARD
drugs are effective at fighting
the inflammation associated
with rheumatoid arthritis, and
can slow the progress of the
disease considerably when
treatment is offered early
enough. With their ability to
ease the patient into
remission, DMARD class drugs
are generally regarded as the
most effective treatment option
for rheumatoid arthritis
patients.
In general DMARDs can take up
to two to three months to take
maximum effect. DMARDs can be
used in conjunction with other
types of drug therapies.
However, most patients find
that the need for other
anti-inflammatory drugs is
greatly reduced or even
eliminated. Although DMARDs are
not a magical solution that
works for everyone, they have
proven effective in helping
millions of rheumatoid
arthritis sufferers enter
remission or at least
experiencing a substantial
lessening of symptoms. For most
patients, DMARDs are prescribed
on a long-term basis. This is
true of most drug therapies
that are currently available to
rheumatoid arthritis
patients.
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Researchers have also found that environmental factors
may also play a role in the cause of rheumatoid arthritis. In
fact, scientists reported that smoking tobacco increases risk
in the development of rheumatoid arthritis.
The symptoms of rheumatoid arthritis depend on the degree of
tissue inflammation. Rheumatoid arthritis is said to be active
if the body tissues are inflammed. When the tissue inflammation
subsides, rheumatoid arthritis is said to be in remission.
Remissions may happen spontaneously or with treatment and can
last for weeks, months, even years. During active rheumatoid
arthritis, symptoms are felt. Symptoms may include fatigue,
lack of appetite, low grade fever, and muscles and joint aches.
Muscles and joint stiffness are usually felt during mornings
and after a period of inactivity. During relapses (from
inactivity to activity) of rheumatoid arthritis, joints become
red, swollen, painful, and tender. This happens because the
tissue lining of the joints become inflamed which results in
the excess production of joint fluids.
Multiple joints are usually inflamed in symmetrical pattern and
the joints of both hands and wrists are often affected. Simple
tasks such as turning the door knob and opening the jars can be
painful. Rheumatoid arthritis can also affect the joint
responsible for the tightening of vocal cords to change the
tone of the voice although rarely. But when this happens, it
can cause hoarseness of the voice.
As mentioned before, rheumatoid arthritis is a systematic
disease which can affect organs and areas of the body other
than the joints. Sjorgen's syndrome is the inflammation of the
glands of the eyes and mouth which causes dryness. Rheumatoid
inflammation of the lung lining can cause chest pains because
the lung tissue itself is inflamed and nodules of inflammation
also develop within the lungs. Rheumatoid arthritis can also
reduce the number of red blood cells which can result to anemia
and white blood cells which can result to increase risk of
infections. A rare, serious complication of rheumatoid
arthritis is blood vessel inflammation which can impair blood
supply to tissues and lead to death of tissues.
A rheumatologist is a doctor who specializes in arthritis and
other related diseases. The rheumatologist reviews the history
of symptoms, examines the joints, and the other parts of the
body for the inflammation. The diagnosis is usually based on
the pattern of symptoms, the distribution of the inflamed
joints, and the blood and x-rays obtained.
Until now, there is no known cure for rheumatoid arthritis.
Reducing joint inflammation and pain, maximizing joint
function, and preventing joint destruction is the current goal
in treating rheumatoid arthritis. Early medical intervention
has been found to improve outcomes in treatment. Optimal
treatment includes combination of medications, joint
strengthening exercises, joint protection, and patient
education. Treatment is customized according to many factors
such as disease activity, types of joints involved, general
health, age, and occupation. But treatment is most successful
when there is close cooperation between the doctor and the
patient.
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About the Author
Charlene J. Nuble 2005. For up to date links and information
about arthritis, please go to: http://arthritis.besthealthlink.net/ or
for updated links and information on all health related topics,
go to: http://www.besthealthlink.net/
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